Psychotherapy research has shown efficacy for numerous psychotherapeutic interventions, however, about one-third of patients do not respond to psychotherapeutic treatment to a clinically significant degree. Treatment non-response involves severe consequences for patients and confers a high socioeconomic burden. A precise prediction of individual treatment response offers the chance to optimize individual treatment selection and to thus prevent patients from prolonged suffering. Accordingly, the identification of valid (bio)markers as correlates and predictors of clinically meaningful endpoints has become central to the field of psychotherapy. In recent years, research into neurobiological markers of psychotherapy response has yielded promising results. In this symposium, we will present some of the recent advances regarding neurobiological response markers in different mental disorders.
Miriam Schiele will review recent findings on epigenetic mechanisms in anxiety- and stress-related disorders including panic disorder, specific phobia and obsessive-compulsive disorder as well as regarding their potential as predictors and dynamic correlates of clinical response to psychotherapy. Elisabeth Leehr will illustrate the protocol of a proof of principle study investigating the a priori prediction of treatment outcomes in specific phobia and will present preliminary clinical and brain structural data. Kati Roesmann will give insights into electromagnetic signatures of fear generalization in relation to response to exposure therapy in patients with spider phobia. Utilizing electroencephalography, Kathrin Schag will present information processing markers relevant for treatment response to a combined neuromodulation and inhibition training addressing cognitive control in patients binge eating disorder.

Zeitfenster der Veranstaltung (1)

Clinical challenges and the ageing brain

Chair(s): Elisabeth Leehr (Münster), Miriam Schiele (Freiburg)

Presenter(s): Miriam Schiele (Freiburg), Elisabeth Leehr (Münster), Kati Roesmann (Siegen), Kathrin Schag (Tübingen)